Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.
Identifieur interne : 001D22 ( Main/Exploration ); précédent : 001D21; suivant : 001D23Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.
Auteurs : Yutaka Terada [Japon] ; Yuto Shiozaki [Japon] ; Hiroshi Shimoda [Japon] ; Hassan Youssef Abdel Hamid Mahmoud [Japon] ; Keita Noguchi [Japon] ; Yumiko Nagao [Japon] ; Masayuki Shimojima [Japon] ; Hiroyuki Iwata [Japon] ; Takuya Mizuno [Japon] ; Masaru Okuda [Japon] ; Masahiro Morimoto [Japon] ; Toshiharu Hayashi [Japon] ; Yoshikazu Tanaka [Japon] ; Masami Mochizuki [Japon] ; Ken Maeda [Japon]Source :
- The Journal of general virology [ 1465-2099 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Chats, Coronavirus félin (), Coronavirus félin (génétique), Coronavirus félin (métabolisme), Coronavirus félin (pathogénicité), Données de séquences moléculaires, Délétion de séquence, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (métabolisme), Motifs d'acides aminés, Mâle, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (métabolisme), Péritonite infectieuse féline (virologie), Virulence.
- MESH :
- génétique : Coronavirus félin, Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- métabolisme : Coronavirus félin, Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- pathogénicité : Coronavirus félin.
- virologie : Péritonite infectieuse féline.
- Animaux, Chats, Coronavirus félin, Données de séquences moléculaires, Délétion de séquence, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Motifs d'acides aminés, Mâle, Protéines de l'enveloppe virale, Virulence.
English descriptors
- KwdEn :
- Amino Acid Motifs, Animals, Cats, Coronavirus, Feline (chemistry), Coronavirus, Feline (genetics), Coronavirus, Feline (metabolism), Coronavirus, Feline (pathogenicity), Feline Infectious Peritonitis (virology), Male, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Membrane Glycoproteins (metabolism), Molecular Sequence Data, Sequence Deletion, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism), Virulence.
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemistry : Coronavirus, Feline.
- genetics : Coronavirus, Feline, Membrane Glycoproteins, Viral Envelope Proteins.
- metabolism : Coronavirus, Feline, Membrane Glycoproteins, Viral Envelope Proteins.
- pathogenicity : Coronavirus, Feline.
- virology : Feline Infectious Peritonitis.
- Amino Acid Motifs, Animals, Cats, Male, Molecular Sequence Data, Sequence Deletion, Spike Glycoprotein, Coronavirus, Virulence.
Abstract
In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP.
DOI: 10.1099/vir.0.043992-0
PubMed: 22718568
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001346
- to stream PubMed, to step Curation: 001346
- to stream PubMed, to step Checkpoint: 001352
- to stream Ncbi, to step Merge: 002521
- to stream Ncbi, to step Curation: 002521
- to stream Ncbi, to step Checkpoint: 002521
- to stream Main, to step Merge: 001D43
- to stream Main, to step Curation: 001D22
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.</title><author><name sortKey="Terada, Yutaka" sort="Terada, Yutaka" uniqKey="Terada Y" first="Yutaka" last="Terada">Yutaka Terada</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shiozaki, Yuto" sort="Shiozaki, Yuto" uniqKey="Shiozaki Y" first="Yuto" last="Shiozaki">Yuto Shiozaki</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shimoda, Hiroshi" sort="Shimoda, Hiroshi" uniqKey="Shimoda H" first="Hiroshi" last="Shimoda">Hiroshi Shimoda</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Mahmoud, Hassan Youssef Abdel Hamid" sort="Mahmoud, Hassan Youssef Abdel Hamid" uniqKey="Mahmoud H" first="Hassan Youssef Abdel Hamid" last="Mahmoud">Hassan Youssef Abdel Hamid Mahmoud</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Keita" sort="Noguchi, Keita" uniqKey="Noguchi K" first="Keita" last="Noguchi">Keita Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Iwata, Hiroyuki" sort="Iwata, Hiroyuki" uniqKey="Iwata H" first="Hiroyuki" last="Iwata">Hiroyuki Iwata</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Mizuno, Takuya" sort="Mizuno, Takuya" uniqKey="Mizuno T" first="Takuya" last="Mizuno">Takuya Mizuno</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Okuda, Masaru" sort="Okuda, Masaru" uniqKey="Okuda M" first="Masaru" last="Okuda">Masaru Okuda</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Masahiro" sort="Morimoto, Masahiro" uniqKey="Morimoto M" first="Masahiro" last="Morimoto">Masahiro Morimoto</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Hayashi, Toshiharu" sort="Hayashi, Toshiharu" uniqKey="Hayashi T" first="Toshiharu" last="Hayashi">Toshiharu Hayashi</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Yoshikazu" sort="Tanaka, Yoshikazu" uniqKey="Tanaka Y" first="Yoshikazu" last="Tanaka">Yoshikazu Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Mochizuki, Masami" sort="Mochizuki, Masami" uniqKey="Mochizuki M" first="Masami" last="Mochizuki">Masami Mochizuki</name><affiliation wicri:level="1"><nlm:affiliation>Food Safety Commission, Cabinet Office, Government of Japan, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food Safety Commission, Cabinet Office, Government of Japan, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Maeda, Ken" sort="Maeda, Ken" uniqKey="Maeda K" first="Ken" last="Maeda">Ken Maeda</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22718568</idno><idno type="pmid">22718568</idno><idno type="doi">10.1099/vir.0.043992-0</idno><idno type="wicri:Area/PubMed/Corpus">001346</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001346</idno><idno type="wicri:Area/PubMed/Curation">001346</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001346</idno><idno type="wicri:Area/PubMed/Checkpoint">001352</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001352</idno><idno type="wicri:Area/Ncbi/Merge">002521</idno><idno type="wicri:Area/Ncbi/Curation">002521</idno><idno type="wicri:Area/Ncbi/Checkpoint">002521</idno><idno type="wicri:Area/Main/Merge">001D43</idno><idno type="wicri:Area/Main/Curation">001D22</idno><idno type="wicri:Area/Main/Exploration">001D22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.</title><author><name sortKey="Terada, Yutaka" sort="Terada, Yutaka" uniqKey="Terada Y" first="Yutaka" last="Terada">Yutaka Terada</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shiozaki, Yuto" sort="Shiozaki, Yuto" uniqKey="Shiozaki Y" first="Yuto" last="Shiozaki">Yuto Shiozaki</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shimoda, Hiroshi" sort="Shimoda, Hiroshi" uniqKey="Shimoda H" first="Hiroshi" last="Shimoda">Hiroshi Shimoda</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Mahmoud, Hassan Youssef Abdel Hamid" sort="Mahmoud, Hassan Youssef Abdel Hamid" uniqKey="Mahmoud H" first="Hassan Youssef Abdel Hamid" last="Mahmoud">Hassan Youssef Abdel Hamid Mahmoud</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Keita" sort="Noguchi, Keita" uniqKey="Noguchi K" first="Keita" last="Noguchi">Keita Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Iwata, Hiroyuki" sort="Iwata, Hiroyuki" uniqKey="Iwata H" first="Hiroyuki" last="Iwata">Hiroyuki Iwata</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Mizuno, Takuya" sort="Mizuno, Takuya" uniqKey="Mizuno T" first="Takuya" last="Mizuno">Takuya Mizuno</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Okuda, Masaru" sort="Okuda, Masaru" uniqKey="Okuda M" first="Masaru" last="Okuda">Masaru Okuda</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Masahiro" sort="Morimoto, Masahiro" uniqKey="Morimoto M" first="Masahiro" last="Morimoto">Masahiro Morimoto</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Hayashi, Toshiharu" sort="Hayashi, Toshiharu" uniqKey="Hayashi T" first="Toshiharu" last="Hayashi">Toshiharu Hayashi</name><affiliation wicri:level="1"><nlm:affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Yoshikazu" sort="Tanaka, Yoshikazu" uniqKey="Tanaka Y" first="Yoshikazu" last="Tanaka">Yoshikazu Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Mochizuki, Masami" sort="Mochizuki, Masami" uniqKey="Mochizuki M" first="Masami" last="Mochizuki">Masami Mochizuki</name><affiliation wicri:level="1"><nlm:affiliation>Food Safety Commission, Cabinet Office, Government of Japan, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food Safety Commission, Cabinet Office, Government of Japan, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Maeda, Ken" sort="Maeda, Ken" uniqKey="Maeda K" first="Ken" last="Maeda">Ken Maeda</name><affiliation wicri:level="1"><nlm:affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea><wicri:noRegion>Yamaguchi 753-8515</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs</term><term>Animals</term><term>Cats</term><term>Coronavirus, Feline (chemistry)</term><term>Coronavirus, Feline (genetics)</term><term>Coronavirus, Feline (metabolism)</term><term>Coronavirus, Feline (pathogenicity)</term><term>Feline Infectious Peritonitis (virology)</term><term>Male</term><term>Membrane Glycoproteins (chemistry)</term><term>Membrane Glycoproteins (genetics)</term><term>Membrane Glycoproteins (metabolism)</term><term>Molecular Sequence Data</term><term>Sequence Deletion</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Envelope Proteins (chemistry)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (metabolism)</term><term>Virulence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chats</term><term>Coronavirus félin ()</term><term>Coronavirus félin (génétique)</term><term>Coronavirus félin (métabolisme)</term><term>Coronavirus félin (pathogénicité)</term><term>Données de séquences moléculaires</term><term>Délétion de séquence</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires ()</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Motifs d'acides aminés</term><term>Mâle</term><term>Protéines de l'enveloppe virale ()</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Péritonite infectieuse féline (virologie)</term><term>Virulence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus, Feline</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus, Feline</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus félin</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus, Feline</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus félin</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus, Feline</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus félin</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Péritonite infectieuse féline</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feline Infectious Peritonitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term><term>Animals</term><term>Cats</term><term>Male</term><term>Molecular Sequence Data</term><term>Sequence Deletion</term><term>Spike Glycoprotein, Coronavirus</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chats</term><term>Coronavirus félin</term><term>Données de séquences moléculaires</term><term>Délétion de séquence</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Motifs d'acides aminés</term><term>Mâle</term><term>Protéines de l'enveloppe virale</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Terada, Yutaka" sort="Terada, Yutaka" uniqKey="Terada Y" first="Yutaka" last="Terada">Yutaka Terada</name></noRegion><name sortKey="Hayashi, Toshiharu" sort="Hayashi, Toshiharu" uniqKey="Hayashi T" first="Toshiharu" last="Hayashi">Toshiharu Hayashi</name><name sortKey="Iwata, Hiroyuki" sort="Iwata, Hiroyuki" uniqKey="Iwata H" first="Hiroyuki" last="Iwata">Hiroyuki Iwata</name><name sortKey="Maeda, Ken" sort="Maeda, Ken" uniqKey="Maeda K" first="Ken" last="Maeda">Ken Maeda</name><name sortKey="Mahmoud, Hassan Youssef Abdel Hamid" sort="Mahmoud, Hassan Youssef Abdel Hamid" uniqKey="Mahmoud H" first="Hassan Youssef Abdel Hamid" last="Mahmoud">Hassan Youssef Abdel Hamid Mahmoud</name><name sortKey="Mizuno, Takuya" sort="Mizuno, Takuya" uniqKey="Mizuno T" first="Takuya" last="Mizuno">Takuya Mizuno</name><name sortKey="Mochizuki, Masami" sort="Mochizuki, Masami" uniqKey="Mochizuki M" first="Masami" last="Mochizuki">Masami Mochizuki</name><name sortKey="Morimoto, Masahiro" sort="Morimoto, Masahiro" uniqKey="Morimoto M" first="Masahiro" last="Morimoto">Masahiro Morimoto</name><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name><name sortKey="Noguchi, Keita" sort="Noguchi, Keita" uniqKey="Noguchi K" first="Keita" last="Noguchi">Keita Noguchi</name><name sortKey="Okuda, Masaru" sort="Okuda, Masaru" uniqKey="Okuda M" first="Masaru" last="Okuda">Masaru Okuda</name><name sortKey="Shimoda, Hiroshi" sort="Shimoda, Hiroshi" uniqKey="Shimoda H" first="Hiroshi" last="Shimoda">Hiroshi Shimoda</name><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name><name sortKey="Shiozaki, Yuto" sort="Shiozaki, Yuto" uniqKey="Shiozaki Y" first="Yuto" last="Shiozaki">Yuto Shiozaki</name><name sortKey="Tanaka, Yoshikazu" sort="Tanaka, Yoshikazu" uniqKey="Tanaka Y" first="Yoshikazu" last="Tanaka">Yoshikazu Tanaka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D22 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D22 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22718568
|texte= Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22718568" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |